POLYASPARTAMIDE ENCAPSULATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES FOR MAGNETIC HYPERTHERMIA
발표자
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초록
내용
In this study, we prepared superparamagnetic iron oxide nanoparticles (SPIONs) capping oleic acid by thermal decomposition method. The synthesized iron oxide nanoparticles were coated with the polyaspartamide (PA) which are biocompatible, and biodegradable. Polysuccinime (PSI) is the backbone of PA. And multifunctional polymers were grafted on PSI, including hydrophilic O-(2-aminoethyl) polyethylene glycol (PEG) and hydrophobic octadecylamine (C18) for amphiphilic structure, and biotin to interacts with receptors on cancer cell surfaces. The PA-encapsulated SPIONs were applied for magnetic hyperthermia. The structure of the polyaspartamide was confirmed by 1H NMR. The structure and biomedical properties of PA-encapsulated SPIONs were investigated in vitro and in vivo experiments.