Anticancer effect of Flufenamic acid acid-loaded Lauric acid–g-chitosan nanoparticle
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초록
내용
Flufenamic acid (FA) has be widely used as anti-inflammatory agent, but according to study currently, researchers reported that it has anticancer effect against bladder cancer cell. However, solubility of FA against water is very low, which may lead to inefficient anticancer effect. To overcome these obstacle, many of researcher have designed to polymeric micelles composed of hydrophilic and hydrophobic substance in order to deliver insoluble drug at cancer cell. We synthesized lauric acid (LA)-grafted water-soluble chitosan (WC) micelle (LAWC) by coupling agent. Chemical structure of LAWC was confirmed by 1H-NMR and FT-IR. In addition, FA-loaded LAWC (LAWCF) nanoparticles were produced by dialysis method. Their drug contents (DC) and encapsulation efficiency (EE) from LAWCF were calculated by using UV-vis spectrophotometer. These results suggest that it can be applied to anticancer agent against bladder cancer cell. (No. NRF-2016H1D5A1910499).