Preparation and Evaluation of Tropolone-loaded chitosan nanoparticles
발표자
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초록
내용
Tropolone has been used as preserved agent in food. However, utilization of tropolone as preserved agent has been limited because of expensive cost and short half-life. To overcome these obstacle, tropolone was encapsulated to chitosan-graft stearic acid micelle (CSA), which may lead to sustained release of tropolone. The chemical structure of CSA was analyzed by 1H-NMR. Moreover, tropolone loaded CSA nanoparticles (CSAT) were prepared by evaporation method. The contents, encapsulation efficiency and release behavior of tropolone from CSAT were confirmed by UV-vis spectrophotometer. Its particle size and morphological property of CSA and CSAT were confirmed by DLS and TEM. Moreover, cytotoxicity of CSA and CSAT were confirmed by MTT assay in human embryo kidney (HEK 293) cell line. These results suggest that CSA micelle is exceptional drug carrier for sustained release of tropolone. (No. NRF-2016H1D5A1910499).