Preparation of Selective De-Cross-Linking Double-Network Hydrogels for Drug Delivery Applications
발표자
()
초록
내용
Double-network hydrogels with high mechanical strength have been synthesized using the self-immolative monomer (1) and N-isopropylacrylamide (NIPAM) by sequential polymerization and shown chemical transformation by selective de-cross-linking without structural failure owing to chemical orthogonality. The hydrogel can be chemically transformed through the selective de-cross-linking of specific network triggered by a molecular stimulus, which significantly alters physical properties of the material such as tunable toughness and lower critical solution temperature behavior. In addition, the material displayed a thermoresponsive, controlled release. Only after treatment with the stimulus did the hydrogel release cargo molecules on demand via de-cross-linking while maintaining the entire structure.