Vegetable oil Polypeptide Conjugates and Their Antimicrobial Activity
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Polypeptides have attracted increasing attention for applications in biotechnology such as tissue engineering, drug delivery, and antimicrobial resistance. Polypeptides are commonly synthesized via ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs). In this work, vegetable oil such as soybean oil and castor oil were exploited as renewable raw materials for polypeptide synthesis. The polypeptides were synthesized by ring-opening polymerization of NCAs in the presence of vegetable oil-based initiators. NCAs were prepared from various amino acids such as lysine, histidine, and arginine while vegetable oil-based initiator were prepared via epoxidation and oxirane ring-opening by ethylenediamine. The antimicrobial activity of the resultant polypeptide against various targets including viruses, bacteria, fungi, and parasites was also examined.