Elastin-Resilin Block Copolypeptides with Converse Phase Transition Behavior and Their Self-assembled Nanostructures
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Diblock copolymers having different solubilities self-assemble into diverse nanostructures such as micelles, rods, vesicles or lamellae in response to external stimuli. In this study, we report thermally triggered self-assembly of elastin-resilin diblock copolypeptides with converse phase transition behavior. Elastin-based polypeptide (EBP) with lower critical solution temperature (LCST) was genetically fused with resilin-based polypeptide (RBP) having upper critical solution temperature (UCST). The EBP-RBP diblocks with different block lengths were synthesized and their self-assembled nanostructures were characterized at nanoscale. The EBP-RBP diblocks underwent dual phase transitions as a function of temperature, and different nanostructures were formed with reversibility. These switchable nanostructures with dual thermo-responsiveness would be of great potential for biomedical applications.