Polymeric Microspheres Contatining Ceramic Nanoparticles for Dermal Filler Having Long-term Stability and Low Inflammatory Responses
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초록
내용
Natural polymer-based dermal fillers have received significant attention in the field of skin care. However, the degradation time of natural polymer is short after implantation. Although synthetic polymers have a long duration in the body, it causes inflammatory responses by acid byproducts during their degradation. To overcome the limitations, polymeric microspheres containing ceramic nanoparticles were prepared. The polymer microspheres were prepared with ceramic nanoparticles via the double emulsion method. The amount of ceramic nanoparticles and collagen production in HDF were evaluated by TGA and PCR, respectively. Indeed, the ceramic nanoparticles neutralized the acidic microenvironment in the degradation, thereby improving stability and reducing inflammation. In results, the polymeric microspheres including ceramic nanoparticles are expected to be applicable as a new type of dermal filler in wide range of medical devices.