Preparation of multi-channel neural guidance platform and axonal growth control by various factors
발표자
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초록
내용
Peripheral Nervous System(PNS) has a limited ability to regenerate after a traumatic injury. Autologous nerve grafts or nerve allografts remain as the current primary treatment method. However availability of autologous nerve grafts is limited and allografts cause immunogenic problems. Thus researchers have developed neural guidance for the nerve regeneration. In this study, we developed a neural guidance platform to control the axonal growth. We prepared the three-dimensional nerve guidance with the micro-sized hollow channels using Poly Ethylene Glycol as a raw material. Channels are engraved with aligned patterns which mimic a natural extracellular matrix and coated with Polypyrrole which is a conductive polymer. Other studies have shown that neuronal deficits were restored when neurons are cultured on a certain directional surface with electrical stimulations. Therefore, our system have structures that give physical and electrical cues for the growth of axon.