Fabrication of quercetin nanoparticle dispersion by nanoprecipitation
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Producing stable particle dispersions using crystallization is one of the challenging fields, although it is cost-effective and adaptable in industries. Recently, various ingredients are made into nanoparticles, but stable dispersions are still difficult to achieve. In this study, a nanocrystallization method fabricated quercetin nanoparticle dispersions. Quercetin crystallization in presence of polymers occurs when its solution is poured into its antisolvent. At the same time, polymer chains could attach onto crystal surfaces, which disturbs crystal growth. Formation of nanoparticle dispersion depends on concentration, solvent-antisolvent ratio and stabilizing materials such as polymers and surfactants. Some materials have low solubility in a certain solvent, which enables to produce nanoparticle dispersion based on the drowning out crystallization. Nanoparticle dispersion may bring advancement to processing materials into nanoscale, and nanocrystallization could be a novel solution.