Development of Hypoxia Sensitive Activatable Fluorescence Imaging Probe
발표자
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초록
내용
Self-immolative dendrimer has well defined 3-D branched structure with designed for controlled release of various molecules. By the single trigger event release of conjugated molecules at the periphery of dendritic building blocks. If the conjugated molecules was a fluorescent dye, FRET-based self-quenched dye will show fluorescence recovery by the single triggered event. In this study, we modified self-immolative dendron to active at the hypoxic environment. Most solid tumor has a hypoxic condition, which provides the conditions of low oxygen level and abnormal tumor tissue environment. Nitro group which modified in dendrimer core acts hypoxia-sensitive trigger, fluorescent dye was conjugated to dendrimer tail end. Nitro group reduced by metabolic reduction at the hypoxic condition, cascade reaction progressed by carbamate linkage and release fluorescence dye and shows hypoxia sensitive fluorescence recovery.