Microfluidic fabrication of stimuli-responsive drug carriers for controlleddrug release
발표자
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초록
내용
Various stimuli-responsive polymers that respond to internal or external stimuli have emerged as an effective approach for selective drug release at target disease sites. Stimuli-responsive drug carriers (SRDC) in response to tumor-specific pH and reductive conditions can achieve tumor-selective drug release. SRDC that can release drugs by increasing the temperature are efficient for selective accumulation of drugs in the target area. In this study, various SRDC were fabricated via stop-flow lithography (SFL) to achieve controlled drug release. The stimuli-sensitivity and drug release rate of the particles could be fine-tuned by modulating the precursor compositions in the SFL process. In vitro studies demonstrated that encapsulated drugs were efficiently released from the particles under tumor conditions or temperature increase. This result confirmed that SRDC were successfully fabricated by SFL and showed controlled drug release in response to various tumor-related stimuli.