Microfluidic Fabrication of Tubular Hydrogels of Various Geometries
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Through microfluidic system combined with alginate templating method, we have prepared multi-stimuli responsive tubular hydrogels with various geometries. Monomers such as N-isopropylacrylamide, sodium acrylate, and allyl amine were used to get temperature and pH responsive property. Furthermore, simple modification to the microfluidic device was used to prepare different geometries. To get the intended microtube’s diameter, it can be achieved by changing the capillaries size and flow control. In addition, by simply swapping the injected pre-gel solution and adding another capillary into triple channels microfluidic device, single and double-walled microtubes could also be produced. This method is flexible and can be further developed into applications such as artificial human blood vessel.