Microfabrication of multichannel nerve guidance conduit with stem cell recruiting ability for enhanced regenration of peripheral nerve injury
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This paper reports a novel and simple method to fabricate multichannel nerve guidance conduit (NC) with poly(L-lactic-co-ε-carprolactone) (PLCL) immobilized with sumbstance P. Injuries in peripheral nerve system affect a wide population globally, and often result in disabilities in 60%. Various treatments exist, but their usage has been limited due to the problems such as size difference, inappropriate reconnection, regenerative capacity limitation of nerve tissue. Here, we suggest a new method exploiting microtechniques and polymer synthetic engineering to provide nerve guidance conduit with size tunability, increased probability of appropriate reconnection, and increased capacity of regeneration. This method paves the way to overcome the current treatment for peripheral nerve injury, and will be widey used in fabrication of medical device.