Doxorubicin Delivery via Well-Defined Poly(N-vinylpyrrolidone)-<EM>b</EM>-Poly(vinylpyridine) pH-Sensitive Block Copolymer
발표자
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초록
내용
To avoid side effects of anti-cancer drugs, using drug delivery system is important to protect normal organs and save drug dosage. Cancer cell has abnormally active metabolism, so it creates much amount of lactic acid, lower pH than normal cell. Using this factor, if pH-sensitive materials are included in drug delivery system, it would release anti-cancer drug only at tumor cells. Though some pH-sensitive drug delivery studies are done, they still have own drawbacks to be used in human body. Herein we study new and well-defined type of pH-sensitive block copolymers. Poly-vinylpyrrolidone is biocompatible and has better water solubility than poly-ethylene glycol. Vinylpyridine is biocompatible if polymerized, pH-sensitive, and has hydrogen bonding ability against doxorubicin, one of the anti-cancer drugs including hydroxyl groups. This simple drug loading principle will lead multi-drug loading, like paclitaxel, whose better performance were reported if combined with doxorubicin.