Surface Modification and Characterization of Biocompatible Inorganic Additives for Biomedical Applications
발표자
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초록
내용
Poly(L-lactic acid) (PLLA) has been widely used in biomedical applications such as vascular stents due to their superior biocompatibility. However, PLLA produces acidic degradation products that acidify the surrounding tissues. Magnesium hydroxide (MH) can alleviate inflammation by neutralizing pH during the hydrolytic degradation. Despite the advantage of MH, it easily agglomerate together, resulting in poor dispersion in the polymer matrix. In this work, two types of modification methods such as grafting to (GT) and grafting from (GF) were developed to improve the physico-mechanical properties of PLLA composites. The PLLA composites were analyzed by FTIR, TGA, UTM, SEM, and pH test. In addition, the cytotoxicity and inflammatory response of the PLLA composites on HCAECs were evaluated by CCK-8 and IL-6/IL-8 production, respectively. Taken all together, it was confirmed that surface modification could improve the physical and biological properties of MH for biomedical applications.