Thrombus targeting aspirin polyconjugate nanoparticles for near infrared imaging and therapy of thrombotic vascular disease.
발표자
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초록
내용
Thrombus formation is a cause of life-threatening disease such as stoke and myocardial infarction. As a treatment and prevention of vascular disease, aspirin has been widely used in the recent years but is unable to target a thrombus and has short half -life. In this study, we developed thrombus targeting aspirin polyconjugate nanoparticles(T-APP) which possess ability of H2O2 scavenging, a near infrared imaging agents on-demand therapeutic agent for thrombotic vascular diseases. T-APP were H2O2-activatable aspirin polyconjugate particle involving aspirin conjugates, fibrin-specific peptides, and fluorescence IR-780. T-APP inhibited the generation of H2O2 and suppressed the expression of tumor necrosis factor-alpha (TNF-α) and soluble CD4- ligand (sCD40L) in activated platelets, demonstrating its intrinsic antioxidant, anti-inflammatory, and antiplatelet activity. The engineered T-APP offer tremendous translational potential as theranostic agents for thrombotic disorders.