Preparation and Characterization of SPIONs Loaded Poly(Ethylene Glycol)-Poly(Aspartic acid) Copolymer as a Cancer Theragnostic Nanocarrier
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In this study, poly(ethylene glycol)-poly(aspartic acid) (PEG-P(Asp)) block copolymer was synthesized by ring opening polymerization of β-benzyl L-aspartate N-carboxy anhydride (BLA-NCA) using an amine-functionalized PEG macroinitiator and alkaline hydrolysis reaction with NaOH. An anticancer agent doxorubicin (DOX) was introduced to the P(Asp) block by chemical conjugation. The DOX conjugated PEG-P(Asp) (PEG-P(Asp)-DOX), will self-assemble in aqueous media to form micellar nanoparticles (NPs) with an average size of 110 nm and efficiently encapsulated superparamagnetic iron oxide nanoparticles (SPIONs) in its hydrophobic core with high loading capacity. Results from our study demonstrated that PEG-P(Asp)-DOX could be useful to develop a new theragnostic nanocarrier due to self-assembling property, good colloidal stability, biodegradability and high SPIONs loading capacity