Effect of enhanced mechanical augmentation using alginate-graphene oxide composite hydrogel for rotator cuff tendon repair
발표자
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초록
내용
Rotator cuff tendon (RCT) tears cause pain and loss of function. However, RCT repair surgery still has a 94% failure rate and re-tear rate is also very high. In this study, we investigated the effect of mechanical augmentation using a composite biomaterial on the repair of artificially torn RCT in a rat model by providing a higher force than the conventional suture support. Alginate (AG) with biocompatibility and biodegradability was used in the form of a hydrogel sheet and a small amount of graphene oxide (GO) was added to improve the physical properties. The AG-GO composite hydrogel sheet (GO@AGHG) showed higher tensile strength than an AG hydrogel sheet and no cytotoxicity. It was confirmed from histological and biomechanical evaluation that the high degree of RCT repair was achieved by mechanical augmentation using GO@AGHG. Conclusively, GO@AGHG is suggested to be a promising orthopedic implant to promote tendon regeneration by RCT augmentation.