PLGA-coated UiO-66-NH<SUB>2</SUB> Enabled with Dual Drug Delivery for Colorectal Cancer Treatment
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초록
내용
Colorectal cancer is the third most common cause of cancer-related death worldwide. In clinical settings, multiple drugs are often prescribed together due to their synergistic effect on colon cancer therapy. Therefore, we propose UiO-66-NH2 coated with folic acid (FA)-modified poly(lactic-co-glycolic acid) (PLGA) for oral delivery of two different anti-cancer drugs, 5-FU and leucovorin (LV). UiO-66-NH2, a type of metal-organic-framework, possessed many pores, where 5-FU could be entrapped. The constituent ligand could form an amide bond with LV. The drug-loaded UiO-66-NH2 was then coated with FA-modified PLGA to hinder drug release at the upper region of the gastrointestinal tract. FA at the carrier would also work as a targeting agent for colon cancer cells. The carriers herein could release about 90% of both drugs continuously for 24 hours. The work is now in progress to evaluate the carriers with in vivo animal models.