Uniformly aligned composite crystals with drugs via controlled solvent evaporation
발표자
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초록
내용
Evaporative crystallization is one of common processes in the electronical, optical and pharmaceutical industry. Producing uniform crystals in randomly fluctuating solvents is remaining the critical issue. Herein, limited air flow and thermal gradient are used to crystallize the drug through the uniform evaporation rate. We selected acetaminophen and ethyl cellulose (EC), poly(ethylene glycol) diacrylate (PEGDA) and polyethyleneimine (PEI) for materials of compound. It is important to engineer parameters -limited air flow, thermal gradient, presence of polymer- for preparing uniformly aligned crystals. The crystals of acetaminophen have morphologies of overlapped triangles. Depending on the type and content of the polymers, the morphologies changed into rod or thick band shapes. Therefore, composite crystals of drug and polymer could be designed to adapt a specific arrangement by controlling the evaporation rate. Also, it was possible to develop the functional crystallized materials.