Soft Tissue Mimetic Hydrogel Formed via Photopolymerization of Decellularized Porcine Lung Tissue
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초록
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Decellularized extracellular matrix (dECM) hydrogel is a promising candidate as a tissue engineered scaffold. Nonetheless, dECM-based hydrogels have some limitations in terms of fabrication as well as property control. In this study, decellularized porcine lung tissue (DLT) and hyaluronic acid (HA) were hybridized to form soft tissue mimetic hydrogel by photopolymerization. DLT solution was obtained by decellularization and pepsin digestion of porcine lung tissue. After decellularization, cellular components were removed while the protein content was maintained. DLT and HA were modified with methacrylic group, resulting in methacrylated DLT and HA. They were photopolymerized with photoinitiator under UV light irradiation. We evaluated the mechanical properties of DLT-based hydrogel and it showed cytocompatibility.