Injectable Chitosan/Polyethylene glycol Hybrid Hydrogels for Highly Enhanced Adhesive Properties
발표자
()
초록
내용
Chitosan(CH)-based hydrogels have been widely used as bio-adhesives due to mucoadhesive property of chitosan. However, their adhesive strength was impeded due to the rigid crystalline structure of chitosan. In this study, we incorporated PEG into the chitosan hydrogel to reduce the rigidity and induce flexibility of hydrogel structure, therefore enhancing the adhesive strength. CH and PEG were grafted with phenol moieties and crosslinked to form hybrid hydrgels using hoseradish peroxidase (HRP)-catalyzed reaction. The adhesive strength of hydrogels was investigated by varying the contents (0~100%), molecular weight (4,10,20 kDa) and structure (linear or tetra) of PEG. It was found that the hydrogels formed by 70% contents of PEG (10 kDa, linear) showed the highest compressive strength (2.2 MPa), leading to enhanced adhesive strength to 200 kPa. From the obtained results, we suggest that CH/PEG hybrid hydrogels could be promising adhesive biomaterials.