Growth Factor/Antibiotic-loaded PCL/HA Microsphere-Hydrogel System for Effective Bone Regeneration
발표자
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초록
내용
Recently, various studies have been conducted for bone regeneration using microspheres as a bone substitute material. Polycaprolactone (PCL) is widely used as a bone substitute (filler) material, however, it poses poor osteoconductive capacity for bone regeneration. Hyaluronic acid (HA) is a naturally occurring non-immunogenic glycosaminoglycan and plays a significant role as a facilitator of osteogenesis for stem cells. In this study, we fabricated PCL/HA hybrid microspheres by a spray/precipitation method using a double nozzle spray. And we prepared a BMP-2-loaded PCL/HA hybrid microspheres and vancomycin-loaded alginate hydrogel carrier system as an injectable bone filler. The bone regeneration behavior of this BMP-2- and vancomycin-loaded bone filler was investigated using a skull defect model of rat. The BMP-2- and vancomycin-loaded group showed more enhanced bone regeneration than the control group (w/o BMP-2 and vancomycin) and the group with single BMP-2 or vancomycin.