Reactive Oxygen Species (ROS) Responsive Polymer Nanoparticles for Chemo-Photodynamic Cancer Therapy
발표자
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초록
내용
In this study, we developed ROS responsive polymer nanoparticles (NPs) for dual therapies using doxorubicin (DOX) and Pheophorbide a (PhA). Firstly, the anticancer agent DOX was chemically conjugated with poly(ethylene glycol) (PEG) via ROS responsive thioketal (TK) linker. The resulting amphiphilic PEG-TK-DOX conjugate could self-assemble in aqueous media to form self-assembled NPs and demonstrated ROS responsive degradation behavior. The PEG-TK-DOX efficiently encapsulated a PDT agent, PhA, to form NPs with good colloidal stability. The PhA loaded PEG-TK-DOX (PEG-TK-DOX/PhA) NPs showed an average diameter about 180 nm. In order to confirm dual therapeutic effect, toxicity of PEG-TK-DOX/PhA NPs were evaluated in CT-26 cells and showed higher toxicity compared to control groups. This system has the potential to offer synergetic therapeutic effect for the treatment of cancer by combining photodynamic therapy and chemotherapy with in a single nano-particular system.