Degradation-regulatable architectured implantable macroporous scaffold for the spatiotemporal modulation of immunosuppressive microenvironment and enhanced combination cancer immunotherapy
발표자
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초록
내용
A degradation-regulatable architectured implantable macroporous scaffold (Dr-AIMS) is designed to act as a local drug delivery reservoir, modulating the immunosuppressive tumor microenvironment (TME) and activating T-cell-based anti-tumor immunity as well. The Dr-AIMS is fabricated by the crosslink of methacrylate-modified hyauronic acid under frozen state to form the interconnected macroprorous architacture with varied blending ratios, the degradation can be regulated with 10-28 days after implantation in mice. The sustained and localized supply of immunomodulatory drugs from Dr-AIMS facilitated the depletion of MDSCs and M2-like macrophages simultaneously within the tumor tissues, converting immunosuppressive TME into anti-tumor immunity niches. Also, systemic anti-tumor immunity was generated with 10-fold reduced doses, resulting in the prolonged survival of mice after surgery of incompletely removed tumor.