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  발표분야
의료용 고분자 부문위원회 I (영어발표)
  발표구분
초청강연(URL)Invited lectures(URL)
  발표장치
Projector
  제목
Orally Active Heparin Conjugate Augments Drug Distribution and Alleviates the Immunosuppressive Microenvironment by Promoting Tumor Perfusion
  공동저자
  • Jeong Uk Choi (Chonnam National University, 박사, 비회원)
  발표자
Jeong Uk Choi (Chonnam National University , Email: jw******@gm*******, 전화: *******9179
  연구책임자
Jeong Uk Choi (Chonnam National University , Email: jw******@gm*******, 전화: *******9179
  키워드
-
  우수논문발표상
우수논문발표상에 응모하지 않습니다
Orally Active Heparin Conjugate Augments Drug Distribution and Alleviates the Immunosuppressive Microenvironment by Promoting Tumor Perfusion
Jeong Uk Choi
Chonnam National University
Formation of blood clots is common in solid tumors, however their impact on limiting tumor perfusion and drug distribution have not been well established. Here, this study verifies that tumor perfusion is highly limited by cancer-associated thrombosis (CAT), which results in restricted drug distribution and accelerated hypoxia. Administration of an oral heparin conjugate (STP3725) demonstrates prevention of CAT and improves tumor perfusion, potentiating the efficacy of gemcitabine/oxaliplatin by enhancing drug distribution. Furthermore, this decreases hypoxia-related cytokines and MDSCs while increasing the infiltration of effector lymphocytes, leading to transformation into an immune-supportive tumor microenvironment. Collectively, these findings establish a rationale for a new combination strategy of oral anticoagulation therapy with chemotherapy/immunotherapy, which can lead to substantial improvements of current approaches in the clinic.
Keywords: -